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Age, sex, race, and income were considered potential confounders in the relationship between smoking status and the occurrence of disorders based on a theoretical framework illustrated in the constructed Directed Acyclic Graph (DAG) (Supplementary file Figure 1)

At that time, the FDA stated it did not possess the ability to extend tobacco product regulations to these synthetic nicotine products

A smoking habit of as few as five cigarettes a day causes your blood vessels to shrink, which leads to blockages and limits the amount of oxygen that gets to your heart or brain

Gastric acid or bile travels backward into the esophagus, producing an unpleasant sour or bitter taste

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