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Evidence shows that countries, where smoking is decreasing fastest, occur where THR use is increasing and displacing cigarettes and that the quality of evidence related to reduced exposure, reduced harm and modelled long term benefits of THR has strengthened rapidly

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This could also lead to the underreporting of tobacco use in females

Surprisingly, we observed no significant transcriptional differences in other mitochondrial fission (Fis1 and Drp1) or fusion markers (Mfn1 and Mfn2) nor in Tfam expression (Figure 2)