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Suppressing objective disease activity not merely relieving symptoms should be the target outcome, as asymptomatic patients are still at risk of scarring or malignant transformation

Abbreviations ACF: Aberrant crypt foci ADT: Androgen-deprivation therapy AEA: N-arachidonoylethanolamine

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Moreover, as metabolism of varenicline accounts for less than 10% of its clearance, agents known to affect the CYP450 system are not expected to affect the pharmacokinetics of varenicline and therefore dose adjustment would not be required