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The study determined both annual costs and lifetime costs, examining factors such as the annual cost of a pack of cigarettes per day, health care expenditures, income losses and other costs associated with smoking and exposure to secondhand smoke

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136 showed that intranasal administration of cigarette smoke extract-induced TSLP expression in the mouse lung and that blocking TSLP activity inhibited OVA-specific Th2 responses and airway inflammation after concomittant cigarette smoke and OVA exposure