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For more serious outbreaks of oral herpes and genital or anal herpes, the treatment may be used for seven to ten days, and in the most serious cases, aciclovir can be given intravenously

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For the cotinine analysis, 175 L diphenylamine, the internal standard, was added to the urine samples, then 1 mL of each urine sample was hydrolyzed with 50 L of 0.1M sodium hydroxide and extracted with 500 L of chloroform

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