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Dickson RP, Erb-Downward JR, Martinez FJ, Huffnagle GB

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While they lack tobacco leaf content, they still pose risks to oral health, including gum irritation and potential dependence. Chemical Composition and Oral Health Implications Smokeless tobacco products contain a complex mixture of chemicals, including: Nicotine : An addictive substance that constricts blood vessels, reducing blood flow to the gums and impairing healing. Tobacco-specific nitrosamines (TSNAs) : Potent carcinogens linked to oral and other cancers. Sugars and flavorings : Added to enhance taste but contribute to tooth decay

Big League Chew rose to popularity at the same time as the Reagan administration began the war on drugs and during the era of the expansion of the D.A.R.E