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Cell Chem

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We applied RTA analysis determines whether perturbation of rigidity and conformational degrees of freedom at NADH regulatory site could propagate through the protein structure (Pivotal helix, 11 and Rosenman fold) inducing the quantifiable changes in rigidity and available number of degree of freedom at a second distant site (GTP binding region), hence result in allosteric transmission

At the cellular level, we saw that the mitochondria of the muscle, also known as the energy factories of the cell, function less well and that they produce less energy," said study co-author Rob Wst, an assistant professor of human movement sciences at Vrije University, in Amsterdam