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During disease progression, the accumulation of aberrant proteins can overwhelm the cellular chaperone system, as the demand for refolding and clearance exceeds its capacity 97

Wild-type ScGrx7 was studied in parallel and served as a control

Animal studies suggest comparable efficacy (with GHK-Cu entering anagen slightly faster), but no large-scale human trial has compared them head-to-head

They commonly complained of darker tanned skin, in relation to their previous lighter skin tone

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