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Pignatti says that, in his view, although both agencies consider progression-free survival (PFS) as a reasonably likely surrogate endpoint, we considered that PFS could be a relevant clinical endpoint in its own right this has been clear in our anticancer guideline for many years

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From the 14 cases of PanIN tested by GLP1R autoradiography on cryostat sections, 1 of 7 cases of PanIN 1/2 stage was receptor positive, whereas 0 of 7 cases of PanIN 3 stage was positive (Table 2)