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GIP also decreases postprandial glycemia and improves insulin sensitivity

This class of polyphenols have a lower redox potential than oxygen and superoxide radicals, making these antioxidants better suited to bind active oxygen (Duthie and Crozier, 2000)

Additionally, epigenetic differences, such as increased methylation of protective genes, such as DUSP9, in females, may influence insulin sensitivity and drug response [49, 51]

According to the National Institute of Alcohol Abuse and Alcoholism, alcohol consumption also prevents the body from fully utilizing the absorbed nutrients by altering their transport and storage

Other pathways and mediators have also been demonstrated to play a role