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Accordingly, prior studies have shown that APR-246 can bind to specific p53 mutants, restore wild-type activities, and cause tumor suppression in cancer cell lines with hot-spot mutations

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It explains both its ~14.9% peak weight loss in STEP 1 and its dose-limiting nausea profile, gastric-emptying delay is the same pathway that drives upper-GI side effects

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In addition, cardiovascular related somatic symptoms, autonomic effects (dry mouth, sweating, tremor, mydriasis tremor, jaw clenching, and restlessness), and moderate derealization have been observed (de la Torre et al., MDMA induced acute toxic effects are related to its pharmacologic actions