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Hasanuzzaman M, Bhuyan MHMB, Zulfiqar F, Raza A, Mohsin SM, Mahmud JA, et al

Early-phase human trials are small, well-controlled studies centered on safety, reproductive hormones, and surrogate markers such as ovarian reserve tests and sperm parameters ahead of any efficacy trials

doi:10.1016/j.cmet.2011.08.014 9

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In five patients who did not receive dexamethasone treatment, a severe phenotype accompanied by tendon tear or rupture was observed, and the total incidence proportion declined from 0.75% to 0.43% with dexamethasone (Supplementary Table S5)