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Nature Medicine (2015) 10.1038/nm.4000 Comprehensive review of cellular senescence as a driver of age-related pathology and the therapeutic potential of senolytic approaches, providing context for FOXO4-DRI's significance

They also suppress glucagon release, a hormone that raises blood glucose

Recent studies have indicated that potassium regulation can counteract detrimental ion accumulation induced by hypoxia and ischemia (such as Ca 2+ and Na + ), maintain stable myocardial membrane potentials, and prevent mitochondrial dysfunction, which is crucial

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