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If a patient has low bone density, anabolic agents such as teriparatide, abaloparatide, or romosozumab may be utilized to stimulate bone formation pre-operatively to ensure the spine is strong enough to hold the new hardware

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Third, while emerging advanced diagnosis tools such as liquid biopsy and AI-based imaging platforms show tremendous promise, the practical application of these technologies in the clinic is also limited by their prospective validation, standardization, and accessibility (328)