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According to Grigson, Because our preliminary data suggested that patients did better in the study if they were on both the GLP-1 drug and medication for opioid use disorder, in this study, half of the participants will be on methadone and half will be on buprenorphine for opioid use disorder treatment. Because semaglutide is stronger, is dosed weekly instead of daily, and has fewer gastrointestinal side effects than liraglutide, it may be even more effective in reducing craving while increasing real-world treatment adherence

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Semaglutide suppresses appetite by mimicking the GLP-1 hormone, which activates receptors in the brain

Bornfeldt KE

PlexusDx also offers oral formulations of both compounds, along with GLP-Squared (a dual-compound injection combining semaglutide and tirzepatide) for patients who don't respond adequately to single-agent therapy