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The antioxidant properties of several natural compounds related to the activation of NRF-2 have been investigated [43], such as curcumin [97], KIOM-4, Resveratrol, Zinc, Berberine, L-arginine, oleanolic acid, vitamin D, among others, in animal cell cultures, with disagreeing results, mainly focused on the decrease of OS or the increase of elements of antioxidant response through NRF-2 [43]

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