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Definitions: SNRI= Serotonin-norepinephrine reuptake inhibitors

In the context of rare diseases, the distinct characteristics of patient population introduce additional hurdles compared to trials for more common diseases (Table 1)

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The discontinued NCT02472717 trial investigating liraglutide in PsA further illustrates both the pioneering nature and the challenges inherent in this research field ( Importantly, none of the currently available trials specifically target the early PsA window, which is increasingly recognized as a critical period for disease modification

Rights and permissions About this article Cite this article Kalinina, E.V., Gavriliuk, L.A