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Insulin glargine/lixisenatide fixed-ratio combination (iGlarLixi) vs fixed-ratio combination of insulin degludec/liraglutide (IDegLira) in uncontrolled type 2 diabetes: The LixiLan-G Trial. Diabetes Care, vol

Additionally, animal studies have suggested that GLP-1 receptors are present in brain regions involved in stress response, though the clinical significance of this in humans remains unclear

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Metabolism and genetics Individual variations in GLP-1 receptor density and sensitivity affect how strongly any given dose activates the appetite suppression and glucose regulation pathways